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While concerns could arise regarding potential oncogenic effects due to increased GLUT1 expression, existing evidence strongly supports metformins anticancer properties 54,55,56,57,58,59,60

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HLA-DR expression on lymphocyte subsets as a marker of disease activity in patients with systemic lupus erythematosus

Furthermore, the functional relevance of endogenous neurogenesis is unclear due to the reduced survival of newborn cells in the striatum ( In addition to the striatum, several studies have found evidence that the cortex may also be capable of regeneration under certain conditions (Magavi et al., 2000), including after ischemia, albeit with a low number of newly formed neurons (Kornack and Rakic, 2001)