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Presynaptic transient receptor potential channel (TRP channel) receptor activation by PregS modulates glutamate release and increases sEPSC in acutely isolated hilar neurons of the dentate gyrus, an increase that is blocked by TRP channel antagonists (121)

Reported side effects are typically mild and may include: Mild nausea (usually with oral forms) Temporary dizziness Gastrointestinal discomfort Injection site reactions (with injectable form) Most users report no significant side effects, making it an attractive option for those concerned about adverse reactions to traditional medications