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Part of that is the relief of taking action, and part is physiological

The three compounds intersect at cellular energy metabolism: NAD+ as a core coenzyme, MOTS-c as a mitochondrial signaling peptide, and 5-Amino-1MQ as an enzyme inhibitor affecting NAD+ availability

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Most of the side effects are gastrointestinal and might include feelings of early fullness, not having enough appetite, nausea, vomiting, and diarrhea

Excess skin can lead to physical discomfort, including rashes, chafing, and difficulties with physical activity

10.1038/s41392-022-01257-8 50 WuX.WeiS.ChenM.LiJ.WeiY.ZhangJ.et al (2022b)