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We previously showed that GIPR activity in alpha cells potentiates amino-acid-stimulated glucagon secretion in mouse islets 11 , and here we found the same interaction between hGIP and amino acids in human islets using concentrations of amino acids found in the postprandial state (Extended Data Figure 4) 11 , prompting us to ask whether tirzepatide engagement of the GIPR in human islets also enhances the effect of amino acids on glucagon secretion
Kuz'mina, NS
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g , Relative fold change in cell number of the indicated HEK-293T SLC25A39 knockout cells expressing a vector control or SLC25A39 cDNA transduced with the indicated sgRNAs
Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide), also known by its developmental code PNB-0408, is a synthetic oligopeptide developed by researchers at Washington State University as a metabolically stable derivative of angiotensin IV
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