Supplementing with vitamin B12 is common because deficiency is widespread
If left untreated, severe vitamin B12 deficiency can lead to complications such as megaloblastic anemia, nerve damage, and neurological disorders
These results are often better than what people see with diet and exercise alone or some other medications
The methodological quality of the included studies, as assessed through the Jadad and NewcastleOttawa scales, varied from moderate to high, while the GRADE assessment indicated moderate certainty of evidence for serum vitamin B12 increase and low certainty for homocysteine reduction
20% of the over 60s are deficient in B12, and 11% of those who follow a vegan diet are also deficient The most common cause of Vitamin B12 deficiency is pernicious anaemia, however, it is estimated that 20% of the over 60s are deficient in B12, and 11% of those who follow a vegan diet are also deficient
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