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1 2 Meeting highlights from the Pharmacovigilance Risk Assessment Committee (PRAC) 8-11 April 2024 European Medicines Agency

We determined changepoints for trends within each country with joinpoint regression

DKK1 were significantly lower in the KO group in both the mRNA and protein levels

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Currently Available Obesity Treatment Tirzepatide FDA-approved as Zepbound with established dosing, safety monitoring, and commercial availability through standard prescribing channels Non-Alcoholic Steatohepatitis (MASH) Survodutide Glucagon receptor agonism directly promotes hepatic fat oxidation and has shown significant liver fat reduction and histological improvement in Phase 2 MASH trials Type 2 Diabetes with Obesity Tirzepatide Dual incretin mechanism provides potent glucose lowering alongside weight loss

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