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Clin Ther 2012;34(8):1674-1682

doi: 10.1210/clinem/dgaa863

10.1016/j.cmet.2013.02.004 2

Its ability to target growth hormone specifically, without significantly affecting other hormones, makes it a popular choice for minimizing side effects

The correlation coefficient square (r 2 ) must not be less than 0.99 ( Table 2 )

Specific Mechanistic Effects Laboratory studies have documented cagrilintide-associated effects, including: Satiety-promoting signaling linked to reduced food intake Delayed gastric emptying , reflected by slowed gastric transit Reduced post-prandial glucagon secretion Enhanced regulation of energy balance Modulation of hypothalamic appetite centers and feeding-behavior circuits These effects arise from activation of the amylin and calcitonin receptors in appetite-regulating brain regions and peripheral metabolic tissues