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Despite the thermodynamically highly favorable reverse reaction, PfGrx C88S (S 2 ) reacted very slowly with roGFP2 WT (SH) 2 most likely due to the instability and high energy of the Grx(SSR) intermediate

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Monitoring the injection site for 24-48 hours for any concerning symptoms including increasing redness, swelling, pain, or warmth that might indicate infection