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The sarcopenia constraint in older patients GLP-1s change body composition as well as weight, and that matters more with age because reserves are lower to start with

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Emir UE, Auerbach EJ, Van De Moortele PF, Marjaska K, Uurbil K, Terpstra M, et al

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Il GIP, da parte sua, stimola anche il rilascio di insulina in presenza di glucosio e svolge un ruolo complementare nella regolazione del metabolismo energetico

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Bugdaci MS, Zuhur SS, Sokmen M, Toksoy B, Bayraktar B, Altuntas Y

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This effect may be explained by at least three potential mechanisms: (1) enhanced DUB activity reverses stress-induced ubiquitylation on proteasome subunits such as RPN10 or RPN13, which otherwise promotes dissociation of the 19S regulatory particle from the 26S complex

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This "builds over time" narrative is community-reported and aligns loosely with the synaptogenesis framing, but it is anecdote layered on a mechanism story whose foundational papers were retracted

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