This study quantifies the relative contributions of EI versus EE to CagriSema-induced weight loss
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Symptoms appear in infants within four weeks of birth, and diagnosis is based on 5-oxoprolinuria, increased levels of 5-oxoproline in the urine
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Concurrently, AMPK promotes mitochondrial biogenesis and repairs electron transport chain (ETC) complex activity by upregulating PGC-1 and mitochondrial transcription factor A (TFAM), effectively reducing superoxide anion generation caused by electron leakage
Endpoints and assessments The primary endpoint is change in the CDR Sum of Boxes (CDR-SB) score from baseline to week 104 in the treatment group compared with the placebo group