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The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism

The body naturally produces glutathione through the liver

"Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis" (PDF)

Immediate discontinuation and treatment may be required if these reactions occur

Conversely, while broad-spectrum PHD inhibitors (e.g., Roxadustat [489]) promote erythropoiesis to treat anemia, their potential pro-oxidant side effects also require careful evaluation, reflecting the dual nature of intervention strategies

HIFs are key transcriptional regulators mediating cellular adaptation to hypoxic environments [484], primarily regulating the expression of a series of oxygen-dependent genes [485]