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showed that DON prodrug which was daily administrated at a low dose significantly inhibited the growth of EL-4 lymphoma in mice without obvious body weight changes (Lemberg et al., 2018)

This steep Ca 2+ gradient creates a strong driving force for Ca 2+ entry and is maintained by the low Ca 2+ permeability of the resting erythrocyte and high Ca 2+ -extruding capacity through a Ca 2+ ATPase and Na + /Ca 2+ exchanger in the cell membrane

It's usually treated with B12 injections or high-dose oral supplements, dietary advice, and, in some cases, proton pump inhibitors to reduce stomach acid levels

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