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The cell-surface transmembrane E3 ubiquitin ligases Zinc and Ring Finger 3 (ZNRF3) and Ring Finger Protein 43 (RNF43) act as negative feedback regulators of Wnt/-catenin signaling by inducing the degradation of FZD and LRP6 in a DVL-dependent manner, and R-spondin (RSPO) ligand binding to leucine-rich repeat-containing G protein-coupled receptor (LGR) 4/5 receptors can clear ZNRF3 and RNF43 to strengthen Wnt/-catenin signaling

found that in vivo and in vitro, Lithium carbonate (LC) assisted MCT1 localization to mitochondrial membranes and lactate influx into mitochondria

Graphical algorithm for integration of genetic and biological data: proof of principle using psoriasis as a model