Where to inject: The patient leaflet advises keeping a 5 cm distance from your belly button
[3] Meloxicam: MedlinePlus Drug Information
PMID 25535828
A., Bakaloudi, D
With the launch of @EliLillyandCo 's orforglipron (Foundayo) for #obesity, many clinicians are asking how to switch patients who are already on a #GLP1 like semaglutide: Evidence-informed TLDR: semaglutide 1.5-2.0 mg/wk orforglipron max dose for #weightloss If switching from sema 2.4 mg/wk, start orforglipron 9 mg/d one week after the last injection, increase to 14.5 mg in 4 weeks, then increase to 17.2 mg, assuming tolerability Counsel that 5% of weight lost may be regained with this switch for details: 1/ With the launch of @EliLillyandCo 's orforglipron (Foundayo) for #obesity, many clinicians are asking how to switch patients who are already on a #GLP1 like semaglutide: Evidence-informed TLDR: semaglutide 1.5-2.0 mg/wk orforglipron max dose for #weightloss If switching from sema 2.4 mg/wk, start orforglipron 9 mg/d one week after the last injection, increase to 14.5 mg in 4 weeks, then increase to 17.2 mg, assuming tolerability Counsel that 5% of weight lost may be regained with this switch for details: 1/ 2/ If a patient is on semaglutide inj, therapeutic equivalence could be informed by its phase 2 trial (thelancet.com/journals/lance), where sema 0.2-0.3 mg/d (1.4-2.1 mg/wk) resulted in ~11% #weightloss at 52 weeks3/ This 11.2-11.6^% weight loss is similar to the 11.2% #weightloss at 72 weeks in ATTAIN-1 with oforglipron 36 mg/d (nejm.org/doi/full/10.10)4/ If you want to switch from sema 2.4 mg/wk to orforglipron, the ATTAIN-MAINTAIN protocol offers a reasonable starting point: Sema 2.4 mg/wk orforglipron 12 mg (9 mg) x 4 wks 24 mg (14.5 mg) x 4 wks 36 mg (17.2 mg) Remember that available doses on the market are a5/5 Read the package insert for additional information: pi.lilly.com/us/foundayo-us And my orforglipron prescribing 101 at @Medscape medscape.com/viewarticle/pr It would be easier, have fewer side effects, and more efficacy just to prescribe them oral Wegovy Join the conversation
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