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Most patients begin noticing changes around weeks 4-6, with more significant results by weeks 8-12

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10.1016/j.acthis.2023.152118 225 ZhangM

4.1 Possible mechanisms of DKD involving intestinal microflora In recent years, in addition to relatively better understood mechanisms such as inflammation and oxidative stress, some researchers have found a close relationship between DKD and gut microbiota

Michaloglou C, Vredeveld LC, Soengas MS, Denoyelle C, Kuilman T, van der Horst CM et al