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Mech Ageing Dev 127(5):444450 van der Put NMJ, Gabrels F, Stevens EMB, Smeitink JAM, Trijbels FJM, Eskes TKAB, van den Heuvel LP, Blom HJ (1998) A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects

33 DardenteH.MendozaJ.FustinJ

Contrary to these results, cell disruption was clearly observed in a study by Gopinath et al

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Conclusion In sum, perturbation of Met metabolism may promote the damage process of hepatobiliary injury triggered by viral infections/toxins and/or niche abnormalities, with dysregulated inflammatory and immune responses of the liver, and contribute to the obliteration and eventual fibrosis and atresia of the bile ducts in the initiation/progression of BA