Meanwhile, tumor cells can increase FAO levels by upregulating CPT1 expression, and high levels of FAO can promote EMT [100, 132, 133] and foster M2 macrophage polarization, which subsequently leads to the secretion of pro-inflammatory cytokines such as IL-1, thereby augmenting tumor cell motility and proliferative capacity [134]
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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or References Sekar R, Singh K, Arokiaraj AW, Chow BK
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