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10.1128/JB.183.21.6454-6465.2001 J

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Additionally, they can be easily degraded by endogenous nucleases in plasma and tissues

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Use of opioids for an extended period of time may influence the hypothalamic-pituitary-gonadal axis, leading to androgen deficiency that may manifest as low libido, impotence, erectile dysfunction, amenorrhea, or infertility