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Some patients benefit from a maintenance dose lower than their peak therapeutic dose, essentially using GLP-1 as a long-term tool rather than a short-term intervention

260,261,262,263,264 This cascade of events leads to enhanced transcription of innate cytokines in various cell types including vascular endothelial cells, smooth muscle cells, and adipocytes

Should we both be tested for this mutation

doi: 10.1016/j.cell.2017.11.001 87 AliRAWuescherLMDonaKRWorthRG

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1 , 2 The prevalence of chronic kidney disease (CKD) continues to increase and parallels the global increase in the prevalence of obesity and T2D