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Cardiovascular Risk Reduction Semaglutide SELECT trial (17,604 patients) demonstrated 20% MACE reduction in overweight/obese adults with established CVD

Diabetes 67(1):311

People with type 1 diabetes should not use semaglutide, as it is only approved for type 2 diabetes and weight loss in specific situations

The dosage should not be increased if target blood sugar levels are achieved at lower doses

Semaglutide mimics glucagon-like peptide-1 (GLP-1), a gut hormone that slows gastric emptying, amplifies glucose-dependent insulin release, and acts on hypothalamic appetite centers to reduce hunger and food-seeking

Effect Gastric emptying slows by up to 30%, dramatically reducing hunger and blunting blood sugar spikes