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Abstract Background: Withdrawal of semaglutide is frequently followed by weight regain due to compensatory biological changes that prevent the maintenance of long-term weight loss

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It is important to maintain realistic expectations: Weight loss is typically gradual and progressive , not immediate Results vary between individuals based on diet, physical activity, genetics, and adherence Sustainable lifestyle changes including a balanced diet and regular physical activity remain essential alongside any pharmacological treatment Weight may plateau before the maintenance dose is reached

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