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As mentioned before, obesity is associated with a state of chronic, low-grade inflammation characterized by abnormal cytokine production and the activation of inflammatory signaling pathways in adipose tissue [76]

A 1987 study on mice determined oral glutathione to be nontoxic,27 and a 2017 toxicity study (also on mice) found that glutathione's LD (the amount of a substance needed to kill 50% of all test animals in one dose) was 5g/kg.6 An equivalent toxic dose for an 80kg human would be 32.5g, which is more than 32 times the highest amounts used in clinical studies

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Each compound was also incubated in the absence of pancreatin (8.3 L of the oligomer stock solution was diluted with 190 L of TRIS 10 mM pH 7.5)