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The fast reactivity of PAT was confirmed in vivo and in vitro where no PAT could be detected in human serum after ingestion of PAT containing apple juice and a reduction of PAT levels by 94% within two minutes of incubation of PAT in a human blood sample (Rychlik 2003)

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128 A single treatment of Balb/c mice with 520 mg/kg TSN showed very mild liver injury (150 U/L ALT)

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The medications are also being studied in late stages of clinical development for chronic kidney disease and non-alcoholic fatty liver disease, where theyve shown promise