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The new label includes references to some of those postmarketing risks, including intestinal obstruction, [and] severe constipation including fecal impaction. Some patients who took Zepbound have filed lawsuits, accusing Eli Lilly of failing to properly warn them that Zepbound could increase their risk of severe gut problems, including bowel obstructions, pancreatitis, and gastroparesis

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In contrast, cholecystectomized subjects are not capable of eliciting a rapid release of BAs into the duodenum in response to food intake

Salem, J.-E

doi:10.1038/s41366-022-01213-0 232

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