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International journal of physiology, pathophysiology and pharmacology, 2018, 10(3): 132

Semaglutide, marketed as Ozempic, Wegovy, and Rybelsus, is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management and chronic weight management

also found an upregulation of the autophagy marker protein LC3 downstream of CHAC1, suggesting an autophagy-mediated induction of ferroptosis (Ying et al., 2025)

(1) Persistence of treatment was defined as the percentage of patients continuing treatment from the time of prescription until evidence of discontinuation

Another systematic review assessed the effects of SAMe in comparison with placebo or antidepressants for the treatment of depression in adults with MDD, with less support for firm conclusions [191]

Some studies have also shown improvements in libido and mood associated with clomiphene supplementation in hypogonadal patients