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Supplementing TMLHE-knockdown cells or mildronate-treated cells with l-carnitine, but not KG, reversed sensitivity to DNA-damaging agents, confirming that KG was upstream of TMLHE-catalysed carnitine synthesis (Fig

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After 26 weeks, along with a greater change in HbA1c from baseline, no changes in renal function were observed with liraglutide when compared to placebo

Additionally, thioredoxin-1, a core component of the thioredoxin system, also contributes to these protective effects by maintaining cellular redox balance (237, 238)

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