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Beyond-use dates include a safety margin, and a vial stored under ideal conditions may retain potency for some time beyond the assigned BUD

STEP 5 demonstrated that semaglutide effects persist when administration continues

Common Side Effects : Insomnia, jitteriness, increased heart rate, anxiety, and digestive upset

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Furthermore, the degree of this GLP-1 effect on the DMN correlated with how much weight and appetite the patients lost - those who had the biggest GLP-1-driven changes in DMN connectivity also reported the greatest reductions in hunger and achieved larger body mass index (BMI) drops post-surgery