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Semaglutide and Tirzepatide are both GLP-1 receptor agonists, with Tirzepatide having additional action on and a higher affinity for glucose-dependent insulinotropic polypeptide (GIP) receptors

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S., Sarraju A., Sandhu A

Switching from Semaglutide to Tirzepatide Switching from Semaglutide to Tirzepatide should be done under medical supervision, as both drugs have different mechanisms and dosing schedules

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Hence, the ongoing FLOW trial (NCT03819153) is assessing the effects of semaglutide on complex renal outcomes in patients with diabetic kidney disease [265]